Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
Categories
Primary Antibodies
Cellular Localization
Mitochondria
Clonality
polyclonal
Description
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Host
Rabbit
Immunogen
adenylate kinase 2
Isotype
IgG
Molecular Weight
33 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Mitochondrion
Synonyms
Adenylate kinase 2, ADK2, AK 2, AK2, ATP AMP transphosphorylase 2
Uniprot
P54819
Gene Id
204
Research Area
Metabolism
Weight
26kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)