This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm
Clonality
polyclonal
Description
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Host
Rabbit
Immunogen
adenylate kinase 1
Isotype
IgG
Molecular Weight
21 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm
Synonyms
Adenylate kinase 1, Adenylate kinase isoenzyme 1, AK 1, AK1, ATP AMP transphosphorylase 1, Myokinase
Uniprot
P00568
Gene Id
203
Research Area
Metabolism
Weight
22kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)