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Home / Primary Antibodies

AIFM1 Antibody / AIF / Apoptosis-Inducing Factor

SKU : BHA17102637

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NSJ Bioreagents

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Mfr.No.	F54034
Clonality	Monoclonal
Description	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. (UniProt)
Formulation	Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host	Mouse
Immunogen Region	A human recombinant partial protein was used as the immunogen for this AIF antibody.
Isotype	IgG2a
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	AIFM1
Uniprot	O95831
Clone No	8H1-B10-A12

Format	Purified
Purification	Protein G affinity
Storage	Store the AIF antibody at -20°C.

Applications	WB, ICC, IF
Dilution	Western blot: 1:1000,ICC/Immunofluorescence: 1:200

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17102637	F54034	0.1 ml	$379		Add to Cart

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