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Home / Primary Antibodies / Polyclonal Antibodies

AIF1 antibody

SKU : BHA10809933

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Mfr.No.	FNab09944
Background	AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.
Clonality	polyclonal
Host	Rabbit
Immunogen	allograft inflammatory factor 1
Immunogen Region	allograft inflammatory factor 1
Isotype	IgG
Molecular Weight	16 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:500-1:2000
Synonyms	AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1

Uniprot	P55008
Gene Id	199
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Stem Cells, Immunology, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09944.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809933	FNab09944	100ug	$260		Add to Cart

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