Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling(By similarity).
Categories
Primary Antibodies
Cellular Localization
Cytoplasm
Clonality
polyclonal
Description
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
Host
Rabbit
Immunogen
axin interactor, dorsalization associated
Isotype
IgG
Molecular Weight
35 kDa
Reactivity
Human
Regulatory
RUO
Subcellular Location
cytoplasm
Synonyms
AIDA, C1orf80, FLJ12806, FLJ32421, RP11 378J18.7
Uniprot
Q96BJ3
Gene Id
64853
Research Area
Developmental biology
Weight
35kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)