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Home / Primary Antibodies / Polyclonal Antibodies

AGS3 antibody

SKU : BHA10800219

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Mfr.No.	FNab00221
Alternative Names	AGS3 ; DKFZp727I051 ; GPSM1
Background	GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory(GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate(GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein(p-CREB).
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, endoplasmic reticulum, Golgi Apparatus, Membrane
Clonality	polyclonal
Description	GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate (GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein (p-CREB).
Host	Rabbit
Immunogen	G-protein signaling modulator 1(AGS3-like, C. elegans)
Isotype	IgG
Molecular Weight	72 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane
Synonyms	AGS3, DKFZp727I051, GPSM1

Uniprot	Q86YR5
Gene Id	26086
Research Area	Cell Division and Proliferation, Developmental biology, Signal Transduction
Weight	72kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, IF, WB

Description

ELISA ; IHC ; IF ; WB

Dilution

WB	1:200-1:2000
IF	1:10-1:100
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800219	FNab00221	100ug	$240		Add to Cart

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