Required for vesicle docking or fusion during acrosome biogenesis(By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic Vesicle, Nucleus
Clonality
polyclonal
Description
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Host
Rabbit
Immunogen
ArfGAP with FG repeats 1
Isotype
IgG
Molecular Weight
58 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasmic vesicle, Nucleus
Synonyms
AGFG1, ArfGAP with FG repeats 1, DKFZp686I15205, HIV 1 Rev binding protein, HRB, Nucleoporin like protein RIP, RAB, Rev interacting protein, RIP
Uniprot
P52594
Gene Id
3267
Research Area
Developmental biology, Immunology, Signal Transduction
Weight
58kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)