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Home / Primary Antibodies / Polyclonal Antibodies

AGER antibody

SKU : BHA10810358

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Mfr.No.	FNab10403
Background	Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Clonality	polyclonal
Host	Rabbit
Immunogen	advanced glycosylation end product-specific receptor
Immunogen Region	advanced glycosylation end product-specific receptor
Isotype	IgG
Molecular Weight	40-55 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:200-1:2000; IHC: 1:20-1:200
Subcellular Location	secreted, cell membrane
Synonyms	AGER, RAGE

Uniprot	Q15109
Gene Id	177
Research Area	Developmental biology, Immunology, Signal Transduction

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:200-1:2000; IHC: 1:20-1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10403.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810358	FNab10403	100ug	$240		Add to Cart

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