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Home / Primary Antibodies / Polyclonal Antibodies

AFF4 antibody

SKU : BHA10800195

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Mfr.No.	FNab00197
Alternative Names	AF4/FMR2familymember4 ; AF4/FMR2family ; member4 ; AF5Q31 ; AFF4 ; MCEF ; ProteinAF5q31
Background	Key component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
Host	Rabbit
Immunogen	AF4/FMR2 family, member 4
Isotype	IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	AF4/FMR2 family member 4, AF4/FMR2 family, member 4, AF5Q31, AFF4, MCEF, Protein AF 5q31

Uniprot	Q9UHB7
Gene Id	27125
Research Area	Cancer, Metabolism
Weight	127kDa,observed 150kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IP

Description

ELISA ; WB ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:1000

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800195	FNab00197	100ug	$240		Add to Cart

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