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Home / Primary Antibodies / Polyclonal Antibodies

AFF1 antibody

SKU : BHA10800193

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Mfr.No.	FNab00195
Alternative Names	AFF1 ; MLLT2 ; AF4MLL ; PBM1 ; AF4
Background	This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	AFF1, also named as AF4, FEL, MLLT2 and PBM1, belongs to the AF4 family. A chromosomal aberration involving AFF1 is associated with acute leukemias. The antibody is specific to AFF1.
Host	Rabbit
Immunogen	AF4/FMR2 family, member 1
Isotype	IgG
Molecular Weight	131 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	AFF1, MLLT2, AF4 MLL, PBM1, AF 4

Uniprot	P51825
Gene Id	4299
Research Area	Cancer, Metabolism
Weight	131kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:1000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

Manual	FNab00195.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800193	FNab00195	100ug	$240		Add to Cart

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