Can cross-link actin filaments into both network and bundle structures(By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, cytoskeleton
Clonality
polyclonal
Description
Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
Host
Rabbit
Immunogen
actin filament associated protein 1
Isotype
IgG
Molecular Weight
81 kDa, 110 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm, Cytoskeleton
Synonyms
AFAP, AFAP 110, AFAP1, FLJ56849
Uniprot
Q8N556
Gene Id
60312
Research Area
Signal Transduction
Weight
81kDa,observed 110kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)