Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate(GHB) to succinic semialdehyde(SSA) coupled to reduction of 2-ketoglutarate(2-KG) to D-2-hydroxyglutarate(D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate(L-3-OHB) are also substrates for HOT with 10-fold lower activities.
Categories
Primary Antibodies
Cellular Localization
Mitochondria
Clonality
polyclonal
Description
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
Host
Rabbit
Immunogen
alcohol dehydrogenase, iron containing, 1
Isotype
IgG
Molecular Weight
50 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Mitochondrion
Synonyms
ADH8, ADHFE1, FLJ32430, HMFT2263, HOT
Uniprot
Q8IWW8
Gene Id
137872
Research Area
Metabolism
Weight
50kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)