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Home / Primary Antibodies / Polyclonal Antibodies

ADCY6 antibody

SKU : BHA10800156

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Mfr.No.	FNab00157
Alternative Names	AC6 ; ADCY6 ; adenylatecyclase6 ; Adenylatecyclasetype6 ; AdenylatecyclasetypeVI ; Adenylylcyclase6 ; ATPpyrophosphatelyase6 ; DKFZp779F075 ; KIAA0422
Background	Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors(PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells(PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion(By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function(By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol(PubMed:17916776). Contributes to bone cell responses to mechanical stimuli(By similarity).
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).
Host	Rabbit
Immunogen	adenylate cyclase 6
Isotype	IgG
Molecular Weight	131 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	cell Membrane
Synonyms	AC6, ADCY6, adenylate cyclase 6, Adenylate cyclase type 6, Adenylate cyclase type VI, Adenylyl cyclase 6, ATP pyrophosphate lyase 6, DKFZp779F075, KIAA0422

Antigen	ADCY6
Uniprot	O43306
Gene Id	112
Research Area	Signal Transduction, Metabolism
Weight	131kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IP

Description

ELISA ; WB ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:1000

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800156	FNab00157	100ug	$240		Add to Cart

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