AC3 is typically found at 130 kDa in olfactory tissues.In nonolfactory tissues (such as sperm), this protein is reported to migrate with a molecular mass of 55 kDa,occasionally accompanied by additional bands at either 90 or 130 kDa(PMID:9539154).
Categories
Primary Antibodies
Cellular Localization
Membrane, Ytoplasm
Clonality
polyclonal
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Host
Rabbit
Immunogen
adenylate cyclase 3
Isotype
IgG
Molecular Weight
170-180 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Membrane,cytoplasm
Synonyms
AC III, AC3, ADCY3, adenylate cyclase 3, Adenylate cyclase type 3, Adenylate cyclase type III, Adenylyl cyclase 3, ATP pyrophosphate lyase 3, KIAA0511
Uniprot
O60266
Gene Id
109
Research Area
Signal Transduction, Metabolism, Neuroscience
Weight
129kDa,observed 170-180kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)