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Home / Primary Antibodies / Polyclonal Antibodies

ADAM17-Specific antibody

SKU : BHA10800138

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Mfr.No.	FNab00139
Alternative Names	ADAM17 ; ADAM17 ; CD156b ; cSVP ; Snakevenomlikeprotease ; TACE ; TNFalphaconvertase ; TNFalphaconvertingenzyme
Background	The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
Host	Rabbit
Immunogen	ADAM metallopeptidase domain 17
Isotype	IgG
Molecular Weight	29 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Membrane
Synonyms	ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme

Uniprot	P78536
Gene Id	6868
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Weight	93kDa,observed 29kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IHC: 1:20-1:200

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800138	FNab00139	100ug	$240		Add to Cart

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