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Home / Primary Antibodies / Polyclonal Antibodies

ADAM17 antibody

SKU : BHA10800137

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Mfr.No.	FNab00138
Alternative Names	ADAM17 ; ADAM17 ; CD156b ; cSVP ; Snakevenomlikeprotease ; TACE ; TNFalphaconvertase ; TNFalphaconvertingenzyme
Background	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Host	Rabbit
Immunogen	ADAM metallopeptidase domain 17
Isotype	IgG
Molecular Weight	115 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Membrane
Synonyms	ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme

Uniprot	P78536
Gene Id	6868
Research Area	Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Weight	93kDa,observed 75kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab00138.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800137	FNab00138	100ug	$240		Add to Cart

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