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Home / Primary Antibodies / Polyclonal Antibodies

ACVR1C antibody

SKU : BHA10800129

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Mfr.No.	FNab00130
Alternative Names	ACVR1C ; Activinreceptortype1C ; ActivinreceptortypeIC ; ACVRLK7 ; ALK7
Background	ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 (PubMed 12063393)).
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Host	Rabbit
Immunogen	activin A receptor, type IC
Isotype	IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	membrane
Synonyms	ACVR1C, Activin receptor type 1C, Activin receptor type IC, ACVRLK7, ALK 7

Uniprot	Q8NER5
Gene Id	130399
Research Area	Stem Cells, Signal Transduction, Metabolism
Weight	55kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:1000-1:10000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab00130.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800129	FNab00130	100ug	$260		Add to Cart

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