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Home / Primary Antibodies / Polyclonal Antibodies

ACTN4 antibody

SKU : BHA10800122

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Mfr.No.	FNab00123
Alternative Names	ACTININ4 ; actinin ; alpha4 ; ACTN4 ; Alphaactinin4 ; DKFZp686K23158 ; Factincrosslinkingprotein ; FSGS ; FSGS1 ; Nonmusclealphaactinin4
Background	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein(Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation(PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions(By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA(PubMed:22351778).
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).
Host	Rabbit
Immunogen	actinin, alpha 4
Isotype	IgG
Molecular Weight	105 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	ACTININ 4, actinin, alpha 4, ACTN4, Alpha actinin 4, DKFZp686K23158, F actin cross linking protein, FSGS, FSGS1, Non muscle alpha actinin 4

Uniprot	O43707
Gene Id	81
Research Area	Immunology, Metabolism
Weight	105kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, IP, FC

Description

ELISA ; WB ; IHC ; IF ; IP ; FC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IP	1:500-1:5000
IF	1:10-1:100

Tested Application

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000; IF: 1:10-1:100

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800122	FNab00123	100ug	$240		Add to Cart

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