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Home / Primary Antibodies / Polyclonal Antibodies

ACOX1 antibody

SKU : BHA10800094

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Mfr.No.	FNab00095
Alternative Names	ACOX ; ACOX1 ; AOX ; PALMCOX ; PalmitoylCoAoxidase ; SCOX
Background	The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.It has 3 isoforms produced by alternative splicing with the molecular mass of 70-74 kDa and can be cleaved post-translationally into a 50-kDa and a 22-kDa subunit between Val468 and Ala469 (PMID: 10672038).
Categories	Primary Antibodies
Cellular Localization	Peroxisome
Clonality	polyclonal
Description	Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA.
Host	Rabbit
Immunogen	acyl-Coenzyme A oxidase 1, palmitoyl
Isotype	IgG
Molecular Weight	74 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Peroxisome
Synonyms	ACOX, ACOX1, AOX, PALMCOX, Palmitoyl CoA oxidase, SCOX

Uniprot	Q15067
Gene Id	51
Research Area	Developmental biology, Metabolism
Weight	74kDa,observed 50kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200; IF: 1:50 - 1:200

Manual	FNab00095.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800094	FNab00095	100ug	$240		Add to Cart

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