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Home / Primary Antibodies / Polyclonal Antibodies

Aconitase 1 antibody

SKU : BHA10800086

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Mfr.No.	FNab00087
Alternative Names	ACO1 ; Aconitase ; Aconitase1 ; aconitase1 ; soluble ; ACONS ; Citratehydrolyase ; Ferritinrepressorprotein ; IREBP1 ; IREB1 ; IREBP
Background	The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	ACO1 also known as Cytoplasmic aconitate hydratase is a iron sensor. It binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. It functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. It binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low.
Host	Rabbit
Immunogen	aconitase 1, soluble
Isotype	IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	ACO1, Aconitase, Aconitase 1, aconitase 1, soluble, ACONS, Citrate hydro lyase, Ferritin repressor protein, IRE BP 1, IREB1, IREBP, IREBP1, Iron regulatory protein 1, IRP1

Uniprot	P21399
Gene Id	48
Research Area	Metabolism
Weight	98kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab00087.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800086	FNab00087	100ug	$240		Add to Cart

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