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Home / Primary Antibodies / Polyclonal Antibodies

ABAT antibody

SKU : BHA10800025

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Mfr.No.	FNab00026
Alternative Names	ABAT ; FLJ17813 ; GABAaminotransferase ; GABAAT ; GABAT ; GABAtransaminase ; GABAT ; LAIBAT
Background	4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Categories	Primary Antibodies
Cellular Localization	Mitochondria
Clonality	polyclonal
Description	Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Host	Rabbit
Immunogen	4-aminobutyrate aminotransferase
Isotype	IgG
Molecular Weight	49 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Mitochondrion
Synonyms	ABAT, FLJ17813, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABAT, L AIBAT

Uniprot	P80404
Gene Id	18
Research Area	Metabolism, Neuroscience
Weight	55kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:200-1:2000
IHC	1:20-1:200
IP	1:200-1:2000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab00026.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800025	FNab00026	100ug	$240		Add to Cart

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