JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Polyclonal Antibodies

AATF antibody

SKU : BHA10800024

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Fine Test

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	FNab00025
Alternative Names	AATF ; CHE1 ; CHE1 ; DED ; ProteinAATF ; RbbindingproteinChe1 ; Traube
Background	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Host	Rabbit
Immunogen	apoptosis antagonizing transcription factor
Isotype	IgG
Molecular Weight	63 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube

Uniprot	Q9NY61
Gene Id	26574
Research Area	Metabolism
Weight	63kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF

Dilution

WB	1:200-1:2000
IF	1:10-1:100

Tested Application

WB: 1:200-1:2000; IF: 1:10-1:100

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHA10800024	FNab00025	100ug	$240		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.