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Home / Primary Antibodies / Phospho Antibodies

Anti-PPP1R12A Antibody BHA11304758

SKU : BHA11304758

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Mfr.No.	BS64148
Alternative Names	Protein phosphatase 1 regulatory subunit 12A ; Myosin phosphatase-targeting subunit 1 ; Myosin phosphatase target subunit 1 ; Protein phosphatase myosin-binding subunit ; PPP1R12A
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	12q21.2-q21.31
Clonality	polyclonal
Description	Myosin phosphatase target subunit 1 (MYPT1), also called Myosin-binding subunit of Myosin phosphatase, is one of the subunits and an integral component of the Myosin phosphatase. Myosin phosphatase regulates the interaction of Actin and Myosin downstream of the guanosine triphosphatase Rho, which inhibits Myosin phosphatase through the action of Rho-kinase. MYPT1 promotor contains one Sp1 transcription factor binding site, suggesting that MYPT1 is a housekeeping gene. Myotonic dystrophy protein kinase phosphorylates MYPT1 at Tyrosine 654 to regulate Myosin II phosphorylation. Inhibition of Myosin light chain phosphatase results in Ca2+ sensitization of smooth muscle contraction. This inhibition is modulated through phosphorylation of MYPT1 by a ZIP-like kinase, which associates with MYPTI and phosphoryl-ates the inhibitory site in smooth muscle. The phosphorylation of MYPT1 by protein kinase C results in altered dephosphoryation of Myosin by attenuating the binding of protein phosphatase 1 catalytic subunit (PP1c) and the phosphorylated Myosin light chain to MYPT1. PP1c interacts with at least four binding sties on the amino-terminus of MYPT1.
Host	Rabbit
Immunogen	Synthetic peptide derived from human MYPT1 around the phosphorylation site of T696.
Modification	phospho-T696
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O14974
Uniprot	O14974
Weight	115 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: MYPT1 (phospho-T696) polyclonal antibody detects endogenous levels of MYPT1 protein only when phosphorylated at T696.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304758	BS64148	50µl	$190.44		Add to Cart
BHA11304758	BS64148	100µl	$294.44		Add to Cart

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