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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IKK alpha/CHUK Antibody Picoband®

SKU : BHA21000018

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Mfr.No.	PB9110, PB9110-10ug, PB9110-Biotin, PB9110-Cy3, PB9110-Dylight488, PB9110-Dylight550, PB9110-Dylight594, PB9110-FITC, PB9110-HRP, PB9110-APC, PB9110-PE, PB9110-iFluor647, PB9110-carrier-free
Alternative Names	Inhibitor of nuclear factor kappa-B kinase subunit alpha
Background	IKKA, also known as conserved helix-loop-helix ubiquitous kinase (CHUK) or IKBKA, is a protein kinase that in humans is encoded by the CHUK gene. It is mapped to 10q24.31. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. IKKA is part of the IkappaB kinase complex that plays an important role in regulating the NF-kappaB transcription factor. However, IKKA also has many additional cellular targets, and is thought to function independently of the NF-kappaB pathway to regulate epidermal differentiation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IKK alpha/CHUK Antibody Picoband® catalog # PB9110. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK c
Host	Rabbit
Immunogen Region	E.coli-derived human IKK alpha recombinant protein (Position: V411-E745). Human IKK alpha shares 98% amino acid (aa) sequence identity with mouse IKK alpha.
Isotype	Rabbit IgG
Molecular Weight	85 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Inhibitor of nuclear factor kappa-B kinase subunit alpha;I-kappa-B kinase alpha;IKK-A;IKK-alpha;IkBKA;IkappaB kinase;2.7.11.10;Conserved helix-loop-helix ubiquitous kinase;I-kappa-B kinase 1;IKK1;Nuclear factor NF-kappa-B inhibitor kinase alpha;NFKBIKA;Transcription factor 16;TCF-16;CHUK;IKKA, TCF16;
Tissue Specificity	Widely expressed.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O15111
Gene Id	1147
Gene Name	CHUK
Sequence	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Subcellular Location	Cytoplasm . Nucleus . Shuttles between the cytoplasm and the nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Mock BA, Connelly MA, McBride OW, Kozak CA, Marcu KB (May 1995). "CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19". Genomics27 (2): 34851. 2. Häcker H, Karin M (October 2006). "Regulation and function of IKK and IKK-related kinases".Sci. STKE 2006 (357): re13. 3. Descargues P, Sil AK, Karin M (October 2008). "IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer". EMBO J. 27 (20): 263947. 4. Zhu F, Park E, Liu B, Xia X, Fischer SM, Hu Y (February 2009). "Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis". Histol. Histopathol. 24 (2): 26571.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000018-1	PB9110	100 ug	-	$370		Add to Cart
BHA21000018-3	PB9110-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000018-4	PB9110-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000018-5	PB9110-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000018-6	PB9110-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000018-7	PB9110-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000018-8	PB9110-FITC	100 ug	FITC	$570		Add to Cart
BHA21000018-9	PB9110-HRP	100 ug	HRP	$570		Add to Cart
BHA21000018-10	PB9110-APC	100 ug	APC	$670		Add to Cart
BHA21000018-11	PB9110-PE	100 ug	PE	$670		Add to Cart
BHA21000018-12	PB9110-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000018-13	PB9110-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000018-2	PB9110-10ug	10 ug	Sample	$99		Add to Cart

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