Model Description: These Trp53 flox mice possess loxP sites flanking exons 5-7 . When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene. Click here for more information.
Official Symbol: Trp53
NCBI ID: 22059
MGI ID: 98834
Ensembl ID: ENSMUSG00000059552
Pubmed: Trp53
Human Ortholog: TP53
Nomenclature
C57BL/6JSmoc-Trp53tm2(flox)Smoc
Exon
Exon s
Application
Cancer Research
Disease
Medulloblastoma
Disease
Spontaneous Tumor
KI/KO Gene
Trp53
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Xrcc4-Flox(NM-CKO-2100799) and Nes-cre mice.
Synonyms
bbl, bfy, bhy, p44, p53, Tp53
Reference
Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW, XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83