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Arntl-Flox

SKU : BHAM00026

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200063
Description	Model Description: These mice carry loxP sites flanking exon 8 of Arntl gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Arntl gene. Official Symbol: Arntl NCBI ID: 11865 MGI ID: 1096381 Ensembl ID: ENSMUSG00000055116 Pubmed: Arntl Human Ortholog: ARNTL
Nomenclature	C57BL/6JSmoc-Arntl^{em1(flox)Smoc}
Exon	Exon 8
Application	Studies On The Regulation Of Lipid Metabolism By Peroxisome Proliferator-Activated Receptor Alpha (Pparalpha) And Circadian Rhythm-Related Genes
Disease	Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Arntl
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pdx1-cre mice.
Synonyms	MOP3, Arnt3, Bmal1, BMAL1b, bHLHe5, bmal1b'

Reference	MGI:3844352 Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J, Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 Jul 29;466(7306):627-31

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