T cell factor-4 (Tcf-4, also known as TCF7L2) plays an important role in development and carcinogenesis. It directly binds to cytosolic β-catenin and facilitate its translocation to the nucleus. In the nucleus, these complexes induce expression various target genes. This adenovirus contain full length human TCF4. Reference: Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma. Science (275):1784-1787. 1997