RasGEFs are now seen as signaling adaptors and integrators; they couple various signaling processes at the cell membrane to Ras and thus to changes inside the cell. The best understood signals to Ras derive from receptor tyrosine kinases (RTKs). When RTKs are stimulated by their ligands, they recruit adaptors such as Grb2, which bind directly to RasGEFs. This recruitment localizes the RasGEFs to the membrane and thus brings them into proximity with Ras. Other RasGEFs are activated by different signals, for example Ca2+ , but the underlying mechanism is thought to be similar.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
RasGEF(1alpha)
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of RasGEF domain family, member 1A Adenovirus (Ad-RasGEF(1alpha))