PUMA (DBH3) Adenovirus (Ad-PUMA (DBH3))

Mfr.No.	1289
Description	PUMA (p53 up-regulated modulator of apoptosis) is a BH3-only protein. Each of the BH3-only group of proteins contains an amphipathic Bcl-2 homology (BH) domain. These proteins act as sensors of discrete apoptotic stimuli, antagonizing or activating the function of multidomain Bcl-2 family proteins by interacting with them. This in turn triggers a cascade of downstream events, such as the collapse of mitochondrial membrane potential, release of the apoptogenic mitochondrial proteins cytochrome c and SMAC, and activation of caspases.PUMA plays a vital role in mediating the apoptotic responses to p53. It can be activated by p53 directly through p53-responsive elements in its promoter region. The PUMA protein interacts with Bcl-XL and promotes mitochondrial translocation and multimerization of Bax.This adenovirus expresses human PUMA gene with a 15-aa deletion of the BH3 domain.Reference: Yu J., et al., Mol Cell. 2001 Mar;7(3):673-82. PUMA induces the rapid apoptosis of colorectal cancer cells.
Categories	Adenovirus, Over-Expression
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Reporter	eGFP
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	PUMA (DBH3)
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Reporter	eGFP
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600050	1289	200 µL	$475		Add to Cart