The platelet derived growth factor receptor (PDGFR) family comprises PDGFR-(alpha) and PDGFR-(beta), which are structurally related and endowed with protein tyrosine kinase domains. These receptors bind the three PDGF ligand isoforms with different affinities. PDGFR-(alpha) can bind to both A and B subunits of PDGF, while PDGFR-(beta) can only bind the B subunit. Chromosomal translocation of the PDGFR-beta gene is linked with chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
PDGF-R(beta)
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Platelet-derived growth factor receptor, beta polypeptide Adenovirus (Ad-PDGF-R(beta))