Phospholamban (PLB, sarco(endo)plasmic-reticulum (SER) regulatory protein) is a 52 amino acid phospho-protein that assembles into a pentamer in the plasma membrane of SER cardiac, smooth and slow-twitch muscle. PLB may regulate cardiac contractility through modulation of SER Ca2+ ATPase (SERCA2a). Nonphosphorylated PLB binds to SERCA2a and inhibits Ca2+ re-uptake into the SER. Phosphorylation of PLB causes dissociation from SERCA2a, allowing Ca2+ uptake into the SER and subsequent ventricular relaxation.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
Phospholamban
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Phospholamban Adenovirus (Ad-Phospholamban)