Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NFkB and other signaling pathways through the adapter protein MyD88. MyD88 functions as an adapter protein in the association of IL-1 receptor associated kinase (IRAK) with the IL-1 receptor. MyD88 contains a characteristic N-terminal death domain, which is essential for NF-kB activation, and an adjacent Toll/Il-1R homology domain (TIR domain), which is responsible for signal transduction. Mal (MyD88 adapter-like, also designated TIR domain-containing adapter protein (TIRAP), wyatt, or TLR-4 adaptor protein) is a cytoplasmic TIR-domain-containing protein that forms homodimers and also heterodimers with MyD88.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
Myd88
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Myeloid differentiation primary response gene (88) Adenovirus (Ad-Myd88)