mouse POU domain, class 5, transcription factor 1 (POU5F1) Adenovirus (Ad-m-Oct4)

Mfr.No.	1792
Description	Oct-3/4 is one of the family of octamer ("Oct") transcription factors, and plays a crucial role in maintaining pluripotency. The absence of Oct-3/4 in Oct-3/4+ cells, such as blastomeres and embryonic stem cells, leads to spontaneous trophoblast differentiation, and presence of Oct-3/4 thus gives rise to the pluripotency and differentiation potential of embryonic stem cells. Various other genes in the "Oct" family, including Oct-3/4's close relatives, Oct1 and Oct6, fail to elicit induction, thus demonstrating the exclusiveness of Oct-3/4 to the induction process.Using adenovirus to deliver these transcription factors has 2 main advantages - it does not incorporate into the targeted host and therefore avoids the potential for insertional mutagenesis, and the expression is transient for a brief amount of time in order for effective reprogramming to take place.This adenovirus expresses mouse Oct3/4, and it can be used in combination with other iPSC factor for the induction of iPSC reprogramming.
Categories	Adenovirus, Over-Expression, iPS stem cell factors
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	m-Oct4
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Species	Mouse
Storage	-80C
Shipping	Dry Ice

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHV21600360	1792	200 µL	$475		Add to Cart