Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1-alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase and catalyzes the hydroxylation of the beta-carbon of asparagine residue 803 within the C-terminal transactivation domain of HIF-1-alpha. This hyroxylation event blocks the association of HIF-1alpha with coactivators.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
HIF1AN/FIH1
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Hypoxia-inducible factor 1, alpha subunit inhibitor Adenovirus (Ad-HIF1AN/FIH1)