Human Klf4-Oct4-Sox2-c-Myc (KOSM) Adenovirus (Ad-h-OKSIM)

Mfr.No.	1784
Description	Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. A major limitation of this technology is the use of potentially harmful genome-integrating viruses. Adenovirus is unique from other viral vectors like lentiviruses and retroviruses because it does not incorporate any of its own genes into the targeted host and therefore avoids the potential for insertional mutagenesis. Another advantage of using adenoviruses is that they only need to present for a brief amount of time in order for effective reprogramming to take place.This KOSM adenovirus express all 4 human transcription factors (Klf4, Oct3/4, Sox2 and c-Myc) joined by three different self-cleaving 2A peptides and IRES, which support efficient polycistronic expression from a single promoter and reduce the number of viruses necessary to reprogram somatic cells.
Categories	Adenovirus, Over-Expression, iPS stem cell factors
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	h-OKSIM
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Species	Human
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600352	1784	200 µL	$495		Add to Cart