Estrogen and progesterone receptors are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The C-terminal region of the estrogen receptor contains a ligand binding domain, the N-terminus serves as a transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER(alpha) and ER(beta), which are differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B), which arise from alternative splicing. In most cells, PR-B functions as a transcriptional activator of progesterone-responsive genes, whereas PR-A functions as a transcriptional inhibitor of all steroid hormone receptors. mPR is a membrane progestin receptor.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
ER-beta
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Estrogen receptor 2 (ER beta) Adenovirus (Ad-ER-beta)