Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Adenovirus (Ad-p18)

Mfr.No.	1407
Description	A family of cell cycle regulatory proteins designated mitotic inhibitors plays a major role in regulating progression through the cell cycle. These proteins bind to cyclin dependent kinases and inhibit the catalytic activity of the Cdk-cyclin complexes. Members of the mitotic inhibitor family include p21, p27, p57, p16, p15, p18 and p19. p19 ARF is an alternative splice product of the murine p16 gene and is known to induce cell cycle arrest. The human homolog p14 ARF induces cell cycle arrest in both G1 and G2/M in a p53-dependent fashion. Kip2 p57, a negative regulator of cell proliferation, inhibits several G1 cyclin/CDK complexes. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression.
Categories	Adenovirus, Over-Expression
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	p18
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600106	1407	200 µL	$690		Add to Cart