Cre and mCherry expressing (RGD fiber modified) Adenovirus (Ad(RGD)-mCherry-iCre)

Mfr.No.	1771
Description	The cell entry of adenovirus is dependent on the initial recognition of the coxsackie-adenovirus receptor (CAR) on the surafce, therefore the infection efficiency of adenovirus is very low for cells with low or no CAR receptor. An Arg-Gly-Asp (RGD) motif was introduced in the surface-exposed loop of the adenovirus fiber knob, this enables the adenovirus to bypass CAR and mediate cell entry via RGD binding integrins.RDG modified adenovirus can be used for "retargeting" cells that regular adenovirus doesn't work well. The infection effeciency of RDG modified adenovirus can be tens or hundreds of times higher than standard Ad5 in some cells, including human or mouse macrophages and T cells etc.This is a RGD modified replication-deficient adenovirus expressing codon optimized Cre and mCherry under a CMV promoter. The Cre and mCherry are separated by a 2A peptide.
Categories	Adenovirus, Over-Expression, Fiber-modified Ad5
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Reporter/Tag
Promoter	CMV (ubiquitous)
Reporter	mCherry
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3) with RGD-fiber modification
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	mCherry-iCre
Serotype	RGD
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Reporter	mCherry
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600339	1771	200 µL	$495		Add to Cart