BRCA1 Adenovirus (Ad-BRCA1)

Mfr.No.	1351
Description	The breast cancer susceptibility gene, BRCA1, which maps to chromosome 17q is expressed in numerous tissues, including breast and ovary. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast and ovarian cancer. Mutations within the BRCA1 gene may account for at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer.This adenovirus expresses the human BRCA1 transcript variant 5 (NM_007299). This variant differs in the 5' UTR, uses two alternate in-frame splice sites in the central coding region, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. So this variant is shorter and has a distinct C-terminus, compared to BRCA1 isoform 1.Please contact us if you need adenoviruses expressing other isoforms of human BRCA1.
Categories	Adenovirus, Over-Expression
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	BRCA1
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600054	1351	200 µL	$475		Add to Cart