A mutated form of estrogen ligand-binding domain (ERT2) that binds to synthetic antagonists (such as tamoxifen or its derivative 4-hydroxy-tamoxifen) but not to circulating estrogens was fused to the Cre recombinase (Cre) to create the CreERT2, which requires the presence of tamoxifen for Cre recombinase activity. Therefore it makes possible to induce the recombination in cells with tamoxifen.This AAV-8 virus expresses CreERT2 under a CMV promoter.
Categories
AAV, Over-Expression, Cre Recombinases
Product Type
Pre-Made
Virus Type
AAV
Function
Recombinase
Promoter
CMV (ubiquitous)
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
CreERT2
Serotype
AAV2/8
Availability
Ready to Ship
Titer
1x10^13 GC/ml
ITRs
AAV2
Reviews of AAV-CReERT2 (AAV serotype 8) AAV (AAV8-CreERT2)